HSD11B1

Across TCGA pan-cancer cohorts, HSD11B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSD11B1 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HSD11B1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HSD11B1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where HSD11B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.903	0.672	.001	28	view →
LUAD	OS	Quartile	II,III,IV	0.307	1.000	.010	15	view →
CCRCC	DFS	Median	II,III,IV	0.198	0.915	.010	6	view →
HNSC	DFS	Quartile	II,III,IV	0.881	1.000	.017	6	view →
PDAC	DFS	Median	III,IV	0.886	0.477	.008	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSD11B1–LSCC (DFS)

Open the LSCC breakdown →