HSD11B1

Across TCGA patient cohorts, HSD11B1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,981 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSD11B1-associated genes across cancer lineages are JAK3, PTGDS, and IL18R1. Each is linked with HSD11B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HSD11B1-to-partner and partner-to-HSD11B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD11B1 versus JAK3 in BRCA, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B1→partner) and Y-score (partner→HSD11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JAK3 →	+1.457	+1.185	.004	<.001	3	5
HNSC	PTGDS →	+0.858	+0.808	<.001	<.001	3	5
BRCA	IL18R1 →	+1.142	+1.078	<.001	<.001	3	5
BRCA	CLEC10A →	+1.667	+0.920	<.001	.002	3	5
HNSC	SAMSN1 →	+0.870	+0.732	<.001	<.001	3	5
HNSC	CCL19 →	+2.219	+0.813	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,981 associations by consensus.

HSD11B1 vs JAK3 — BRCA

Explore this scatter interactively →