HSD11B1

Across TCGA patient cohorts, HSD11B1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD11B1-associated genes across cancer lineages are TFRC, EGFR, and JNK_pT183_Y185. Each is linked with HSD11B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B1-to-partner and partner-to-HSD11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HSD11B1-low versus HSD11B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B1→partner) and Y-score (partner→HSD11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.540	+3.169	.011	.018	3	2
UCEC	EGFR →	-0.205	-3.459	.001	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.180	-1.893	.007	.016	3	1
UCEC	mTOR_pS2448 →	-0.165	-3.446	.005	.005	3	1
UCEC	mTOR →	-0.165	-1.906	.011	.016	3	1
UCEC	Notch1 →	+0.198	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TFRC by HSD11B1 expression — UCEC

Explore this box plot interactively →