HSD11B1

Across TCGA cell cohorts, HSD11B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,846 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSD11B1-associated GO terms across cancer lineages are Viral life cycle, Urokinase plasminogen activator signaling pathway, and Protein activation cascade. Each is linked with HSD11B1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HSD11B1-to-partner and partner-to-HSD11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral life cycle grouped by HSD11B1-low versus HSD11B1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B1→partner) and Y-score (partner→HSD11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Viral life cycle →	+0.107	+1.344	<.001	.006	3	10
BREAST	Urokinase plasminogen activator signaling pathway →	+1.076	+0.705	<.001	.003	2	10
SOFT_TISSUE	Protein activation cascade →	+0.295	+1.197	<.001	.004	2	10
LIVER	Biological process involved in symbiotic interaction →	+0.128	+1.367	<.001	.002	3	9
LIVER	Biological process involved in interaction with host →	+0.120	+1.312	.001	.007	3	9
BREAST	Blood coagulation, fibrin clot formation →	+0.309	+0.499	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,846 associations by consensus.

Viral life cycle by HSD11B1 expression — LIVER

Explore this box plot interactively →