HSD11B1

Across TCGA cell cohorts, HSD11B1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HSD11B1-associated genes across cancer lineages are TBC1D28, OR51A4, and SMIM28. Each is linked with HSD11B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD11B1-to-partner and partner-to-HSD11B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D28 grouped by HSD11B1-low versus HSD11B1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD11B1→partner) and Y-score (partner→HSD11B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TBC1D28 →	+0.043	+3.920	<.001	.005	3	1
SKIN	OR51A4 →	+0.008	+4.437	<.001	.004	3	1
SKIN	SMIM28 →	+0.016	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TBC1D28 by HSD11B1 expression — SKIN

Explore this box plot interactively →