Across TCGA pan-cancer cohorts, HSBP1L1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated HSBP1L1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HSBP1L1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HSBP1L1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

LIHC, PAAD, and ACC are the cancer types where HSBP1L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Quartile	All	0.329	0.686	<.001	90	view →
PAAD	OS	Median	All	0.389	0.577	<.001	85	view →
ACC	DFS	Median	II,III,IV	0.244	0.644	<.001	75	view →
KIRC	DFS	Tertile	III,IV	0.375	0.588	.006	64	view →
KICH	DFS	Median	III,IV	0.306	0.882	.010	21	view →
UCEC	DFS	Median	IV	0.497	0.819	.004	20	view →
BRCA	OS	Median	III,IV	0.903	0.756	<.001	19	view →
UCS	DFS	Median	IV	0.440	0.885	.015	18	view →
LGG	DFS	Tertile	All	0.663	0.797	.003	14	view →
CESC	DFS	Tertile	II,III,IV	0.268	0.635	.012	12	view →
PRAD	DFS	Median	All	0.850	0.914	.016	12	view →
BLCA	OS	Quartile	II,III,IV	0.787	0.621	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

Exploration

Same gene, other analysis: HSBP1L1 tumor-vs-normal RNA expression · all HSBP1L1 data types