Across TCGA cell cohorts, HS6ST3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS6ST3-associated genes across cancer lineages are NPY2R, COX6A2, and DEFA4. Each is linked with HS6ST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS6ST3-to-partner and partner-to-HS6ST3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST3→partner) and Y-score (partner→HS6ST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	2
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	TRDN →	+0.030	+4.376	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

HS6ST3 survival (RNA) · tumor vs normal (RNA) · all HS6ST3 data types