HS6ST1

Across TCGA pan-cancer cohorts, HS6ST1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HS6ST1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HS6ST1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HS6ST1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where HS6ST1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	1.000	0.605	.006	13	view →
PDAC	DFS	Median	III,IV	0.489	1.000	.024	4	view →
LSCC	DFS	Median	III,IV	0.925	0.625	.017	2	view →
CCRCC	DFS	Median	III,IV	0.492	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HS6ST1–LUAD (OS)

Open the LUAD breakdown →