HS6ST1

Across TCGA patient cohorts, HS6ST1 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS6ST1-associated genes across cancer lineages are RNU6-751P, RNA5SP416, and MTND6P17. Each is linked with HS6ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS6ST1-to-partner and partner-to-HS6ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-751P grouped by HS6ST1-low versus HS6ST1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST1→partner) and Y-score (partner→HS6ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-751P →	+0.518	+7.930	<.001	.008	3	2
UCEC	RNA5SP416 →	+0.694	+2.546	<.001	.004	3	2
LUSC	MTND6P17 →	+0.103	+7.924	<.001	.008	3	2
UCEC	RNU4-5P →	+0.342	+2.335	.001	.004	3	1
UCEC	ZSWIM8-AS1 →	+0.148	+2.577	.004	.009	3	1
UCEC	CHASERR →	+0.627	+3.584	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

RNU6-751P by HS6ST1 expression — LUAD

Explore this box plot interactively →