HS6ST1

Across TCGA patient cohorts, HS6ST1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS6ST1-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and Smad3. Each is linked with HS6ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS6ST1-to-partner and partner-to-HS6ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by HS6ST1-low versus HS6ST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST1→partner) and Y-score (partner→HS6ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.217	-3.169	.010	.019	3	1
UCEC	Notch1 →	+0.203	+3.013	.004	.018	3	1
UCEC	Smad3 →	+0.179	+2.321	.018	.035	3	1
UCEC	STAT3_pY705 →	-0.406	-2.321	.002	.035	3	1
UCEC	4E-BP1 →	+0.293	+2.837	.031	.035	3	1
UCEC	eEF2 →	+0.463	+3.459	.009	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK_pT183_Y185 by HS6ST1 expression — UCEC

Explore this box plot interactively →