HS6ST1

Across TCGA cell cohorts, HS6ST1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS6ST1-associated genes across cancer lineages are TEX46, H2BW2, and NPFFR1. Each is linked with HS6ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS6ST1-to-partner and partner-to-HS6ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX46 grouped by HS6ST1-low versus HS6ST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS6ST1→partner) and Y-score (partner→HS6ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX46 →	+0.118	+3.302	.008	.008	3	2
BLOOD_Leukemia	H2BW2 →	+0.065	+3.234	.002	.008	3	1
BLOOD_Leukemia	NPFFR1 →	+0.012	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	TACR3 →	+0.025	+3.475	<.001	.006	3	1
BLOOD_Leukemia	RXFP3 →	+0.008	+3.289	.002	.009	3	1
BLOOD_Leukemia	KRTAP4-1 →	+0.027	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TEX46 by HS6ST1 expression — LARGE_INTESTINE

Explore this box plot interactively →