HS3ST5

Across TCGA patient cohorts, HS3ST5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,004 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HS3ST5-associated proteins across cancer lineages are TRIM2, RCOR3, and MAP1B_T1633. Each is linked with HS3ST5 in more than 4 cancer types. Because this analysis shows association rather than direction, both HS3ST5-to-partner and partner-to-HS3ST5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS3ST5 versus TRIM2 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST5→partner) and Y-score (partner→HS3ST5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM2 →	+0.443	+0.335	<.001	.008	3	5
COAD	RCOR3 →	+0.309	+0.222	<.001	.002	3	4
LSCC	MAP1B_T1633 →	+1.192	+0.731	<.001	<.001	3	4
LSCC	PLCB4 →	+0.788	+0.699	<.001	.002	3	4
GBM	CDA →	-0.601	-0.567	.006	.003	3	4
LSCC	CRMP1 →	+0.798	+0.577	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,004 associations by consensus.

HS3ST5 vs TRIM2 — HNSC

Explore this scatter interactively →