HS3ST5

Across TCGA patient cohorts, HS3ST5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST5-associated genes across cancer lineages are Notch1, ASNS, and Annexin_VII. Each is linked with HS3ST5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST5-to-partner and partner-to-HS3ST5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HS3ST5-low versus HS3ST5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST5→partner) and Y-score (partner→HS3ST5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.155	+2.594	.006	.006	3	2
UCEC	ASNS →	+0.441	+2.321	.002	.033	3	2
SKCM	Annexin_VII →	-0.146	-3.000	.029	.035	3	2
LUAD	MSH6 →	+0.581	+2.824	<.001	.034	3	1
LUAD	Beclin →	-0.237	-3.321	<.001	.010	3	1
UCEC	JNK2 →	+0.240	+2.415	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by HS3ST5 expression — UCEC

Explore this box plot interactively →