HS3ST5

Across TCGA cell cohorts, HS3ST5 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HS3ST5-associated genes across cancer lineages are TARM1, NEUROD4, and H2BW1. Each is linked with HS3ST5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST5-to-partner and partner-to-HS3ST5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TARM1 grouped by HS3ST5-low versus HS3ST5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST5→partner) and Y-score (partner→HS3ST5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
BLOOD_Lymphoma	NEUROD4 →	+0.125	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	H2BW1 →	+0.239	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	CBLIF →	+0.095	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	PLCZ1 →	+0.101	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	HTR2C →	+0.831	+4.247	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

TARM1 by HS3ST5 expression — URINARY_TRACT

Explore this box plot interactively →