HS3ST3B1

Across TCGA patient cohorts, HS3ST3B1 mutation is significantly associated with the RNA expression of many other genes, with 944 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST3B1-associated genes across cancer lineages are RTCB, PHF5A, and ADNP2. Each is linked with HS3ST3B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST3B1-to-partner and partner-to-HS3ST3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTCB grouped by HS3ST3B1-low versus HS3ST3B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST3B1→partner) and Y-score (partner→HS3ST3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RTCB →	+0.534	+3.378	.008	.004	3	2
UCEC	PHF5A →	+0.637	+3.700	<.001	.001	3	2
UCEC	ADNP2 →	+0.619	+3.362	.006	.005	3	2
UCEC	HSPA9 →	+0.532	+3.346	.004	.005	3	2
UCEC	RARS1 →	+0.491	+3.403	.003	.004	3	2
UCEC	SLC17A5 →	+0.659	+3.338	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 944 associations by consensus.

RTCB by HS3ST3B1 expression — UCEC

Explore this box plot interactively →