HS3ST3B1

Across TCGA cell cohorts, HS3ST3B1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS3ST3B1-associated genes across cancer lineages are ASB10, PRAMEF7, and CPO. Each is linked with HS3ST3B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST3B1-to-partner and partner-to-HS3ST3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB10 grouped by HS3ST3B1-low versus HS3ST3B1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST3B1→partner) and Y-score (partner→HS3ST3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB10 →	+0.126	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.009	+4.539	.008	.007	3	1
LARGE_INTESTINE	CPO →	+0.132	+3.514	<.001	.007	3	1
LARGE_INTESTINE	FANCD2OS →	+0.172	+3.667	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASB10 by HS3ST3B1 expression — BLOOD_Leukemia

Explore this box plot interactively →