HS3ST3A1

Across TCGA patient cohorts, HS3ST3A1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST3A1-associated genes across cancer lineages are 14-3-3_beta, Notch1, and p62 Lck ligand. Each is linked with HS3ST3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST3A1-to-partner and partner-to-HS3ST3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HS3ST3A1-low versus HS3ST3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST3A1→partner) and Y-score (partner→HS3ST3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.088	-2.295	.025	.033	3	2
UCEC	Notch1 →	+0.113	+1.584	.041	.036	3	2
UCEC	p62 Lck ligand →	+0.370	+2.179	.003	.034	3	2
UCEC	eIF4E →	+0.222	+3.169	.007	<.001	3	1
UCEC	A-Raf_pS299 →	-0.151	-3.321	.001	.010	3	1
UCEC	Fibronectin →	-0.302	-1.990	.019	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by HS3ST3A1 expression — UCEC

Explore this box plot interactively →