HS3ST3A1

Across TCGA cell cohorts, HS3ST3A1 mutation is significantly associated with the mutation status of many other genes, with 1,286 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS3ST3A1-associated genes across cancer lineages are CARMIL1, TRAPPC12, and PCDH8. Each is linked with HS3ST3A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST3A1-to-partner and partner-to-HS3ST3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARMIL1 grouped by HS3ST3A1-low versus HS3ST3A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST3A1→partner) and Y-score (partner→HS3ST3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CARMIL1 →	+4.772	+5.339	.004	.004	1	3
STOMACH	TRAPPC12 →	+4.807	+4.807	.008	.008	1	3
BLOOD_Leukemia	PCDH8 →	+3.309	+4.794	.002	.002	1	3
LARGE_INTESTINE	TMC2 →	+2.630	+3.047	.005	.005	1	3
LARGE_INTESTINE	JARID2 →	+1.992	+3.963	.001	.001	1	2
BLOOD_Leukemia	SMARCD3 →	+4.309	+4.560	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,286 associations by consensus.

CARMIL1 by HS3ST3A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →