HS3ST3A1

Across TCGA cell cohorts, HS3ST3A1 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HS3ST3A1-associated genes across cancer lineages are XMD14-99, VE-822, and 630600. Each is linked with HS3ST3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST3A1-to-partner and partner-to-HS3ST3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XMD14-99 grouped by HS3ST3A1-low versus HS3ST3A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST3A1→partner) and Y-score (partner→HS3ST3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	XMD14-99 →	+0.356	+2.652	.032	.045	3	2
LARGE_INTESTINE	VE-822 →	+0.567	+2.646	.048	.047	3	1
LARGE_INTESTINE	630600 →	+0.853	+2.649	.005	.046	3	1
LARGE_INTESTINE	Genentech Cpd 10 →	+0.620	+2.652	.041	.045	3	1
LARGE_INTESTINE	CAY10603 →	+0.463	+2.652	.042	.045	3	1
LARGE_INTESTINE	Fedratinib →	+0.607	+2.652	.019	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

XMD14-99 by HS3ST3A1 expression — LARGE_INTESTINE

Explore this box plot interactively →