HS3ST1

Across TCGA pan-cancer cohorts, HS3ST1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HS3ST1 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HS3ST1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HS3ST1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

LUSC, KICH, and UCEC are the cancer types where HS3ST1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	OS	Median	All	0.964	0.659	.040	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	III,IV	0.040	0.361	<.001	6	view →
SKCM	DFS	Median	III,IV	0.058	0.648	.001	3	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HS3ST1–LUSC (DFS)

Open the LUSC breakdown →