HS3ST1

Across TCGA pan-cancer cohorts, HS3ST1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HS3ST1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HS3ST1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HS3ST1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, GBM, and LUAD are the cancer types where HS3ST1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.224	0.497	.004	50	view →
GBM	OS	Tertile	All	0.221	0.619	.007	14	view →
LUAD	OS	Median	All	0.537	0.826	.003	7	view →
HNSC	OS	Median	IV	0.887	0.537	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HS3ST1–PDAC (OS)

Open the PDAC breakdown →