HS3ST1

Across TCGA pan-cancer cohorts, HS3ST1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HS3ST1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where HS3ST1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HS3ST1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

PDAC, HNSC, and LSCC are the cancer types where HS3ST1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS3ST1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	+1.129	<.001	7	view →
HNSC	All	All	−0.544	.007	7	view →
LSCC	Male	All	+0.715	<.001	6	view →
LUAD	Male	All	+0.391	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HS3ST1–PDAC

Open the PDAC breakdown →