HS3ST1

Across TCGA patient cohorts, HS3ST1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,341 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HS3ST1-associated proteins across cancer lineages are PRPF6, PUS1, and RAD50. Each is linked with HS3ST1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS3ST1 versus PRPF6 in LSCC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRPF6 →	-0.265	-0.916	<.001	<.001	3	4
OV	PUS1 →	-0.442	-0.526	.001	.002	3	4
COAD	RAD50 →	-0.445	-0.437	<.001	.009	3	4
LUAD	ARFIP1 →	+0.231	+0.782	.001	.002	3	4
BRCA	ITGAM →	+0.712	+0.631	<.001	<.001	3	4
COAD	MRE11 →	-0.492	-0.714	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,341 associations by consensus.

HS3ST1 vs PRPF6 — LSCC

Explore this scatter interactively →