HS3ST1

Across TCGA patient cohorts, HS3ST1 protein abundance is significantly associated with the protein abundance of many other proteins, with 3,530 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HS3ST1-associated proteins across cancer lineages are ANKZF1_T607, ARID4B_S666, and ANGPTL4. Each is linked with HS3ST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS3ST1 versus ANKZF1_T607 in PDAC, with a Pearson correlation of 0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ANKZF1_T607 →	+0.466	+0.878	<.001	<.001	3	2
PDAC	ARID4B_S666 →	-1.051	-0.878	.001	.001	3	2
PDAC	ANGPTL4 →	+1.321	+1.183	<.001	<.001	3	2
HNSC	ATP5F1E →	-0.656	-0.647	<.001	<.001	3	2
PDAC	ACOX1 →	+0.535	+0.938	<.001	<.001	3	2
GBM	ELANE →	+1.565	+0.588	.002	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,530 associations by consensus.

HS3ST1 vs ANKZF1_T607 — PDAC

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