HS3ST1

Across TCGA patient cohorts, HS3ST1 mutation is significantly associated with the RNA expression of many other genes, with 1,530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST1-associated genes across cancer lineages are SFXN1, ADAM33, and CCDC3. Each is linked with HS3ST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFXN1 grouped by HS3ST1-low versus HS3ST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SFXN1 →	+0.466	+2.243	<.001	.001	3	3
UCEC	ADAM33 →	-0.760	-3.647	.005	.001	3	2
UCEC	CCDC3 →	-0.666	-2.137	.006	.001	3	2
UCEC	CENPU →	+0.557	+1.839	.005	.002	3	2
UCEC	BAG3 →	+0.737	+2.479	<.001	.001	3	2
SKCM	AP1S3 →	+0.604	+3.182	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,530 associations by consensus.

SFXN1 by HS3ST1 expression — UCEC

Explore this box plot interactively →