HS3ST1

Across TCGA patient cohorts, HS3ST1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HS3ST1-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and ATM. Each is linked with HS3ST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HS3ST1-low versus HS3ST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.429	+1.415	.033	.046	3	3
UCEC	JNK_pT183_Y185 →	-0.169	-1.401	.007	.046	3	3
UCEC	ATM →	-0.692	-3.807	<.001	<.001	3	3
UCEC	MEK1 →	+0.398	+2.700	.003	.006	3	2
UCEC	Akt →	-0.187	-1.797	.029	.025	3	2
UCEC	Annexin-1 →	+0.710	+2.135	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GAPDH by HS3ST1 expression — UCEC

Explore this box plot interactively →