HS3ST1

Across TCGA cell cohorts, HS3ST1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,466 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HS3ST1-associated GO terms across cancer lineages are Negative regulation of hippocampal neuron apoptotic process, Regulation of potassium ion import, and Regulation of hippocampal neuron apoptotic process. Each is linked with HS3ST1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hippocampal neuron apoptotic process grouped by HS3ST1-low versus HS3ST1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of hippocampal neuron apoptotic process →	+1.435	+2.123	.006	.001	3	10
STOMACH	Regulation of potassium ion import →	+0.212	+1.542	.002	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of hippocampal neuron apoptotic process →	+1.527	+1.958	.008	<.001	2	10
URINARY_TRACT	Maintenance of blood-brain barrier →	+0.207	+2.327	<.001	.001	3	9
URINARY_TRACT	Clathrin coat disassembly →	+0.174	+2.311	.004	<.001	3	9
PANCREAS	Response to interleukin-1 →	+0.090	+1.451	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

Negative regulation of hippocampal neuron apoptotic process by HS3ST1 expression — URINARY_TRACT

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