HS3ST1

Across TCGA cell cohorts, HS3ST1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HS3ST1-associated genes across cancer lineages are FAM83C, CCDC182, and MROH2B. Each is linked with HS3ST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HS3ST1-to-partner and partner-to-HS3ST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM83C grouped by HS3ST1-low versus HS3ST1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HS3ST1→partner) and Y-score (partner→HS3ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAM83C →	+0.226	+4.115	<.001	.002	3	1
OVARY	CCDC182 →	+0.057	+3.700	.002	.005	3	1
OVARY	MROH2B →	+0.049	+4.339	<.001	.001	3	1
OVARY	SPATA8 →	+0.064	+3.938	<.001	.005	3	1
LARGE_INTESTINE	MYH2 →	+0.044	+2.672	.008	.004	3	1
LARGE_INTESTINE	KLHDC7B →	+0.671	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FAM83C by HS3ST1 expression — OVARY

Explore this box plot interactively →