HS2ST1

Across TCGA patient cohorts, HS2ST1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,454 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HS2ST1-associated proteins across cancer lineages are TUT4, PAIP1, and PIGT. Each is linked with HS2ST1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HS2ST1-to-partner and partner-to-HS2ST1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HS2ST1 versus TUT4 in HNSC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HS2ST1→partner) and Y-score (partner→HS2ST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TUT4 →	+0.297	+0.472	.001	.004	3	4
LSCC	PAIP1 →	+0.335	+0.477	.001	<.001	3	3
LUAD	PIGT →	+0.388	+0.554	<.001	<.001	3	3
LSCC	SYTL1 →	-0.352	-0.406	.001	.002	3	3
PDAC	P4HA1 →	+0.501	+0.310	<.001	<.001	3	3
PDAC	PLOD2 →	+0.630	+0.370	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,454 associations by consensus.

HS2ST1 vs TUT4 — HNSC

Explore this scatter interactively →