HS1BP3

Across TCGA pan-cancer cohorts, HS1BP3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HS1BP3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HS1BP3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HS1BP3 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where HS1BP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HS1BP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.271	<.001	9	view →
LSCC	All	II,III,IV	−0.191	<.001	8	view →
HNSC	Male	III,IV	+0.189	<.001	8	view →
PDAC	Female	II,III,IV	+0.381	<.001	6	view →
CCRCC	Male	All	+0.148	<.001	6	view →
LUAD	Male	III,IV	−0.246	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HS1BP3–COAD

Open the COAD breakdown →