Across TCGA pan-cancer cohorts, HRNR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HRNR data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HRNR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HRNR expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, GBM, and LSCC are the cancer types where HRNR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.936	0.715	.022	4	view →
GBM	DFS	Tertile	All	0.325	0.460	.048	2	view →
LSCC	DFS	Quartile	All	1.000	0.932	.043	1	view →
HNSC	DFS	Median	IV	0.978	0.605	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: HRNR tumor-vs-normal RNA expression · all HRNR data types