Across TCGA patient cohorts, HRNR RNA expression is significantly associated with the protein abundance of many other proteins, with 7,503 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HRNR-associated proteins across cancer lineages are PAFAH2, NOTCH3, and TRAP1. Each is linked with HRNR in more than 3 cancer types. Because this analysis shows association rather than direction, both HRNR-to-partner and partner-to-HRNR results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HRNR→partner) and Y-score (partner→HRNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAFAH2 →	-0.268	-0.701	.005	.007	3	4
HNSC	NOTCH3 →	+0.434	+0.669	.002	.003	3	3
UCEC	TRAP1 →	-0.336	-0.738	<.001	.001	3	3
LSCC	NMNAT1_S117 →	-0.677	-0.877	<.001	<.001	3	3
BRCA	PHLDB1_S430 →	+1.022	+0.159	<.001	<.001	3	3
LSCC	SAMD4B_S172 →	+0.389	+0.552	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,503 associations by consensus.

Exploration

HRNR survival (RNA) · tumor vs normal (RNA) · all HRNR data types