Across TCGA patient cohorts, HRNR mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRNR-associated genes across cancer lineages are 4E-BP1_pS65, Caspase-7-cleavedD198, and 4E-BP1_pT70. Each is linked with HRNR in more than 3 cancer types. Because this analysis shows association rather than direction, both HRNR-to-partner and partner-to-HRNR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRNR→partner) and Y-score (partner→HRNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pS65 →	+0.134	+1.415	.007	.045	3	4
COAD	Caspase-7-cleavedD198 →	+0.525	+1.717	.034	.022	3	4
LUAD	4E-BP1_pT70 →	+0.159	+1.431	.019	.028	3	3
LUAD	Cyclin-E1 →	+0.387	+1.765	<.001	.013	3	3
STAD	FASN →	+0.393	+3.185	.024	.009	3	3
LUSC	JNK_pT183_Y185 →	-0.125	-2.321	.003	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

HRNR survival (RNA) · tumor vs normal (RNA) · all HRNR data types