HRNR

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, HRNR mutation is significantly associated with the RNA expression of many other genes, with 383 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HRNR-associated genes across cancer lineages are PRKACG, TBL1Y, and CIAO1. Each is linked with HRNR in more than 2 cancer types. Because this analysis shows association rather than direction, both HRNR-to-partner and partner-to-HRNR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRNR→partner) and Y-score (partner→HRNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
URINARY_TRACTPRKACG →+0.006+5.087<.001.00432
LUNG_NSCLC_LUSCTBL1Y →+0.053+4.643<.001.00832
LARGE_INTESTINECIAO1 →+0.338+3.067.003.00932
LARGE_INTESTINEPWWP3A →+0.631+3.502.005.00132
LARGE_INTESTINEHMGN4 →+0.493+3.502.003.00132
LARGE_INTESTINEMAK16 →+0.780+3.067.002.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

Exploration