Across TCGA cell cohorts, HRNR mutation is significantly associated with the mutation status of many other genes, with 3,167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HRNR-associated genes across cancer lineages are HIVEP1, TTLL12, and CACNA1I. Each is linked with HRNR in more than 5 cancer types. Because this analysis shows association rather than direction, both HRNR-to-partner and partner-to-HRNR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRNR→partner) and Y-score (partner→HRNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HIVEP1 →	+2.867	+2.378	.001	.001	1	6
SKIN	TTLL12 →	+4.282	+2.593	.002	.002	1	5
SKIN	CACNA1I →	+2.282	+2.078	.004	.004	1	5
SKIN	COL20A1 →	+2.282	+2.078	.004	.004	1	5
SKIN	PCDHB6 →	+2.545	+2.222	.002	.002	1	5
SKIN	ASH1L →	+2.867	+2.378	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,167 associations by consensus.

Exploration

HRNR survival (RNA) · tumor vs normal (RNA) · all HRNR data types