HRK

Across TCGA patient cohorts, HRK protein abundance is significantly associated with the RNA expression of many other genes, with 5,515 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HRK-associated genes across cancer lineages are OPN1SW, SLC10A1, and CRYBA1. Each is linked with HRK in more than 3 cancer types. Because this analysis shows association rather than direction, both HRK-to-partner and partner-to-HRK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HRK versus OPN1SW in LUAD, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRK→partner) and Y-score (partner→HRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OPN1SW →	-0.501	-0.605	.002	.004	3	4
LUAD	SLC10A1 →	-0.775	-0.953	<.001	<.001	3	3
LUAD	CRYBA1 →	-0.549	-0.606	.004	<.001	3	3
LUAD	LEAP2 →	-0.509	-0.571	.001	<.001	3	3
LUAD	GPR151 →	-0.225	-0.702	.002	.003	3	3
LSCC	PPIAP67 →	-0.907	-0.546	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,515 associations by consensus.

HRK vs OPN1SW — LUAD

Explore this scatter interactively →