HRK

Across TCGA patient cohorts, HRK protein abundance is significantly associated with the protein abundance of many other proteins, with 15,291 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HRK-associated proteins across cancer lineages are SF3B1_T426, VPS13D_S2671, and ARHGEF2_S941. Each is linked with HRK in more than 4 cancer types. Because this analysis shows association rather than direction, both HRK-to-partner and partner-to-HRK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HRK versus SF3B1_T426 in GBM, with a Pearson correlation of -0.49.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HRK→partner) and Y-score (partner→HRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B1_T426 →	-0.698	-0.773	<.001	.004	3	5
LUAD	VPS13D_S2671 →	+1.266	+0.908	<.001	<.001	3	5
LSCC	ARHGEF2_S941 →	+0.979	+0.829	<.001	<.001	3	5
GBM	DENND4C_S1623 →	+1.662	+1.041	<.001	<.001	3	4
LUAD	AKAP11_T1485 →	+1.351	+0.968	<.001	<.001	3	4
HNSC	PKP3_S238 →	-1.044	-0.832	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,291 associations by consensus.

HRK vs SF3B1_T426 — GBM

Explore this scatter interactively →