HRK

Across TCGA cell cohorts, HRK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,694 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HRK-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, Negative regulation of mRNA metabolic process, and Transposable element silencing by piRNA-mediated heterochromatin formation. Each is linked with HRK in more than 8 cancer types. Because this analysis shows association rather than direction, both HRK-to-partner and partner-to-HRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process grouped by HRK-low versus HRK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HRK→partner) and Y-score (partner→HRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Nuclear-transcribed mRNA catabolic process →	+0.057	+1.086	.002	.001	3	9
STOMACH	Negative regulation of mRNA metabolic process →	+0.069	+0.952	.004	.007	3	8
SKIN	Transposable element silencing by piRNA-mediated heterochromatin formation →	-1.114	-0.738	<.001	<.001	3	8
STOMACH	Regulation of DNA-templated transcription elongation →	+0.068	+1.356	<.001	<.001	3	8
STOMACH	Regulation of transcription elongation by RNA polymerase II →	+0.051	+0.871	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of G2/M transition of mitotic cell cycle →	+0.038	+0.840	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,694 associations by consensus.

Nuclear-transcribed mRNA catabolic process by HRK expression — STOMACH

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