HRH3

Across TCGA patient cohorts, HRH3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRH3-associated genes across cancer lineages are YAP, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with HRH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH3-to-partner and partner-to-HRH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by HRH3-low versus HRH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH3→partner) and Y-score (partner→HRH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YAP →	+0.146	+3.179	.031	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.750	+3.321	.005	.009	3	2
UCEC	14-3-3_beta →	-0.090	-2.973	.046	.035	3	1
UCEC	eIF4E →	+0.211	+3.013	.026	.018	3	1
UCEC	A-Raf_pS299 →	-0.165	-3.459	.002	.005	3	1
UCEC	Ku80 →	+0.236	+2.183	.026	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

YAP by HRH3 expression — UCEC

Explore this box plot interactively →