HRH3

Across TCGA cell cohorts, HRH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,677 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HRH3-associated GO terms across cancer lineages are Regulation of DNA repair, Regulation of calcium ion transport into cytosol, and DNA replication-dependent chromatin disassembly. Each is linked with HRH3 in more than 6 cancer types. Because this analysis shows association rather than direction, both HRH3-to-partner and partner-to-HRH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by HRH3-low versus HRH3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH3→partner) and Y-score (partner→HRH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of DNA repair →	+0.057	+0.275	<.001	.004	2	7
LUNG_SCLC	Regulation of calcium ion transport into cytosol →	-0.270	-2.235	<.001	.001	3	5
BONE	DNA replication-dependent chromatin disassembly →	+0.125	+0.032	.001	.009	3	5
LUNG_SCLC	Regulation of DNA recombination →	+0.082	+2.284	<.001	<.001	3	5
LUNG_SCLC	Positive regulation of double-strand break repair via homologous recombination →	+0.068	+1.690	<.001	<.001	3	5
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.074	+2.129	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,677 associations by consensus.

Regulation of DNA repair by HRH3 expression — SOFT_TISSUE

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