HRH3

Across TCGA cell cohorts, HRH3 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HRH3-associated genes across cancer lineages are C6orf118, OR5V1, and RSPH6A. Each is linked with HRH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH3-to-partner and partner-to-HRH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by HRH3-low versus HRH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH3→partner) and Y-score (partner→HRH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.127	+3.378	<.001	.001	3	2
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	2
CNS	RSPH6A →	+0.025	+3.874	.001	.006	3	1
CNS	ZNF831 →	+0.070	+3.832	<.001	.005	3	1
CNS	IL22RA2 →	+0.425	+4.584	<.001	.001	3	1
CNS	C10orf53 →	+0.059	+4.044	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C6orf118 by HRH3 expression — LARGE_INTESTINE

Explore this box plot interactively →