HRH2

Across TCGA patient cohorts, HRH2 mutation is significantly associated with the RNA expression of many other genes, with 3,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRH2-associated genes across cancer lineages are SNORA10B, ADAM33, and SAR1B. Each is linked with HRH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HRH2-to-partner and partner-to-HRH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA10B grouped by HRH2-low versus HRH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH2→partner) and Y-score (partner→HRH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORA10B →	+0.171	+2.105	<.001	.008	3	3
LUAD	ADAM33 →	-0.586	-3.676	.006	.001	3	3
UCEC	SAR1B →	+0.428	+2.931	.001	<.001	3	3
UCEC	CCDC89 →	-0.810	-3.775	<.001	<.001	3	3
UCEC	SRA1 →	+0.288	+2.329	.002	.003	3	3
CESC	TPRKBP1 →	+0.122	+4.413	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

SNORA10B by HRH2 expression — UCEC

Explore this box plot interactively →