Across TCGA patient cohorts, HRH1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRH1-associated genes across cancer lineages are MEK1, Stathmin, and PCNA. Each is linked with HRH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH1-to-partner and partner-to-HRH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH1→partner) and Y-score (partner→HRH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.381	+1.523	.001	.008	3	2
COAD	Stathmin →	+0.205	+2.815	.015	.036	3	2
UCEC	PCNA →	+0.190	+2.502	.005	.001	3	2
UCEC	ATM →	-0.465	-2.794	.001	.002	3	2
UCEC	Caspase-8 →	-0.268	-2.378	<.001	<.001	3	2
COAD	RAD51 →	+0.196	+2.815	.023	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

HRH1 survival (RNA) · tumor vs normal (RNA) · all HRH1 data types