Across TCGA cell cohorts, HRH1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HRH1-associated genes across cancer lineages are GPHB5, ADIG, and TLE7. Each is linked with HRH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRH1-to-partner and partner-to-HRH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRH1→partner) and Y-score (partner→HRH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPHB5 →	+0.036	+4.887	.004	.009	3	1
BLOOD_Leukemia	ADIG →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.034	+4.969	<.001	.003	3	1
LARGE_INTESTINE	ACER1 →	+0.098	+3.823	.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
BLOOD_Lymphoma	OR52B2 →	+0.039	+4.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

HRH1 survival (RNA) · tumor vs normal (RNA) · all HRH1 data types