HRG

Across TCGA patient cohorts, HRG mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRG-associated genes across cancer lineages are Caspase-7-cleavedD198, TAZ, and ASNS. Each is linked with HRG in more than 2 cancer types. Because this analysis shows association rather than direction, both HRG-to-partner and partner-to-HRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HRG-low versus HRG-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRG→partner) and Y-score (partner→HRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.042	+3.008	.011	.019	3	3
COAD	TAZ →	+0.279	+3.025	.006	.019	3	2
UCEC	ASNS →	+0.361	+2.000	.009	.030	3	2
SKCM	C-Raf →	+0.205	+3.186	<.001	.009	3	2
COAD	PDK1 →	-0.145	-2.991	.012	.036	3	1
UCEC	EGFR →	-0.214	-3.295	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by HRG expression — COAD

Explore this box plot interactively →