HRG

Across TCGA cell cohorts, HRG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,320 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible HRG-associated GO terms across cancer lineages are Positive regulation of inhibitory synapse assembly, Keratinocyte development, and Positive regulation of collagen metabolic process. Each is linked with HRG in more than 6 cancer types. Because this analysis shows association rather than direction, both HRG-to-partner and partner-to-HRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of inhibitory synapse assembly grouped by HRG-low versus HRG-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HRG→partner) and Y-score (partner→HRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of inhibitory synapse assembly →	+0.310	+0.115	.001	<.001	3	7
LUNG_NSCLC_LUSC	Keratinocyte development →	-0.416	-0.437	<.001	.007	3	6
LUNG_NSCLC_LUAD	Positive regulation of collagen metabolic process →	-0.100	-0.117	.003	.005	3	6
LUNG_NSCLC_LUAD	L-histidine transport →	+0.114	+0.139	.001	.001	3	6
SOFT_TISSUE	Regulation of inhibitory synapse assembly →	+0.881	+0.020	.001	.008	3	6
OVARY	Iron coordination entity transport →	+0.120	+0.365	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,320 associations by consensus.

Positive regulation of inhibitory synapse assembly by HRG expression — LUNG_NSCLC_LUAD

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