HRG

Across TCGA cell cohorts, HRG mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HRG-associated genes across cancer lineages are DEFA4, PRSS58, and TBC1D3H. Each is linked with HRG in more than 1 cancer types. Because this analysis shows association rather than direction, both HRG-to-partner and partner-to-HRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by HRG-low versus HRG-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRG→partner) and Y-score (partner→HRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA4 →	+0.024	+4.662	<.001	.005	3	2
PANCREAS	PRSS58 →	+0.084	+5.584	<.001	<.001	3	1
PANCREAS	TBC1D3H →	+1.533	+4.011	<.001	.009	3	1
LUNG_SCLC	CLEC2A →	+0.107	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	1
LARGE_INTESTINE	FRG1 →	+0.430	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

DEFA4 by HRG expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →