Across TCGA patient cohorts, HRCT1 protein abundance is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HRCT1-associated genes across cancer lineages are TVP23BP2, EPB41L4A, and PI15. Each is linked with HRCT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRCT1-to-partner and partner-to-HRCT1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRCT1→partner) and Y-score (partner→HRCT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TVP23BP2 →	-0.481	-0.610	.002	.004	3	1
LSCC	EPB41L4A →	+1.063	+0.815	.001	.007	3	1
LSCC	PI15 →	-1.352	-0.830	.005	.008	3	1
LSCC	BSND →	+0.075	+0.570	.004	.009	3	1
LSCC	GPR155 →	-1.109	-0.575	.004	.003	3	1
LSCC	HTR3A →	+0.577	+0.880	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

HRCT1 survival (RNA) · tumor vs normal (RNA) · all HRCT1 data types