Across TCGA patient cohorts, HRCT1 mutation is significantly associated with the RNA expression of many other genes, with 158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRCT1-associated genes across cancer lineages are LINC01076, FCRL4, and OR4K3. Each is linked with HRCT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRCT1-to-partner and partner-to-HRCT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRCT1→partner) and Y-score (partner→HRCT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01076 →	+0.325	+2.704	<.001	.004	3	2
UCEC	FCRL4 →	+0.175	+3.515	<.001	.003	3	1
UCEC	OR4K3 →	+0.049	+3.274	.006	.001	3	1
UCEC	NEUROG2 →	+1.292	+2.796	<.001	.007	3	1
UCEC	CCL26 →	+1.103	+3.343	<.001	.005	3	1
UCEC	DAZL →	+0.106	+3.976	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 158 associations by consensus.

Exploration

HRCT1 survival (RNA) · tumor vs normal (RNA) · all HRCT1 data types