Across TCGA patient cohorts, HRCT1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HRCT1-associated genes across cancer lineages are Rad50, PEA-15, and Annexin-1. Each is linked with HRCT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HRCT1-to-partner and partner-to-HRCT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRCT1→partner) and Y-score (partner→HRCT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.421	-3.169	.001	.020	3	1
UCEC	PEA-15 →	+0.242	+3.169	.019	.020	1	1
UCEC	Annexin-1 →	+0.769	+3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

HRCT1 survival (RNA) · tumor vs normal (RNA) · all HRCT1 data types